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Derailment
This catastrophic derailment is horrific.
Comments
https://www.thefreedictionary.com/cascade
Going south...
Combine that with the arbitrary convention to orient maps with north pointing up and south pointing down, and you get an idiomatic expression "going south", meaning"turning bad".
"As a minimum requirement, mice used in experiments must be of the same purebred species. Another reason rodents are used as models in medical testing is that their genetic, biological and behavior characteristics closely resemble those of humans, and many symptoms of human conditions can be replicated in mice and rats."